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PIFIR model evaluation in neuropathic pain. Comparison of three antinociceptive schemes in rats

Abstract:

Objective: (1) To assess the effectiveness of the PIFIR model in neuropathic pain. (2) To compare the antinociceptive effect of three analgesic regimes for the control of induced pain. Material and methods: Five groups with six rats each were formed. Group A was the control group and underwent no nerve injury. All the remaining rats underwent a ligature of the sciatic nerve. Rats in Group B received no drugs. Rats in Group C were given parecoxib; rats in Group D received tramadol plus ketorolac; and rats in group E received ketamine. Function of the hind limbs was studied with the PIFIR method. Results were analyzed using the Student's t test and the Mann-Whitney rank sum test. Results: Groups C (parecoxib) and D (tramadol plus ketorolac) showed no significant difference (p = 0.129 and 0.13, respectively) vs. the group with no drug, although Group D showed a slight improvement. Group E showed a statistically significant improvement (p = 0.043). Conclusions: (1) The PIFIR model is useful to evaluate function in rats with induced neuropathic pain. No improvement was observed after parecoxib was administered. Although slight improvement was observed with tramadol plus ketorolac, it was not conclusive. Ketamine achieved a significant improvement.