PMD43 An Evidence-Based Microsimulation Model for Chronic Graft versus Host Disease in Spain

Abstract:

Objectives Rituximab (Rmb), Imatinib (Imt) and extra-corporeal photopheresis (ECP) are some of the strategies used as rescue therapy among patients with chronic graft-versus-host disease (cGVHD) who failes previous lines of treatment. The purpose of the study was to assess the cost-effectiveness of ECP in patients with cGVHD in Spain. Methods A Microsimulation model was built to estimate the clinical and economic consequences of ECP versus Rmb or Imt for 1000 hypothetical patients. Model probabilities concerning the efficacy of ECP, Rtm and Imt and severity degree per organ affected were obtained from literature. Treatment pathways and adverse events were evaluated taking into consideration expert opinion. Local data on costs (Euros 2010) and use of health resources were also validated by clinical experts. An annual 3% discount rate was applied to costs and outcomes. The perspective was the …

Año de publicación:

2011

Keywords:

Fuente:

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