Penicilin acylase mediated synthesis of formyl cefamandole

Abstract:

Penicillin acylase-catalyzed synthesis from D,L-methyl mandelate (1c) and the cefalosporin nucleus (2) at pH 6 gives rise preferentially to the L-diastereoisomer (3a) of cefamandole, whereas D,L-O-formyl methyl mandelate (1f) affords exclusively O-formyl cefamandole (cefamandole nafate) (4), in 30-35% yields. © 1992 Kluwer Academic Publishers.

Año de publicación:

1992

Keywords:

Fuente:

scopus