Peripheral blood CD34+ cell immunomagnetic selection in breast cancer patients: effect on hematopoietic progenitor content and hematologic recovery after high‐dose chemotherapy …

Abstract:

BACKGROUND: Tumor cells have been detected in mobilized peripheral blood of breast cancer patients, and they may contribute to tumor recurrence after the transplantation of peripheral blood progenitor cells. One of the most widespread technologies for tumor purging of the graft is immunomagnetic hematopoietic progenitor cell selection. STUDY DESIGN AND METHODS: The study assessed the effectiveness of a magnetic cell‐separation system in selecting functional subpopulations of hematopoietic progenitors from 14 blood‐derived harvests of 11 patients with high‐risk breast cancer after mobilization following cytotoxic chemotherapy supported by granulocyte–colony‐stimulating factor, as well as the feasibility of transplanting these selected subpopulations. RESULTS: CD34(+)‐enriched cell fractions had a median purity of 93.0 percent (72.7‐98.5%). The procedure yielded 52.6 percent of the CD34+ cell …

Año de publicación:

1998

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