Pharmacogenomics and personality: Role of CYP2D6 and implications for psychopathology

Abstract:

CYP2D6 polymorphism is related to absent (poor metabolizers, PMs) and normal/decreased (extensive metabolizers, including ultrarapid metabolizers) metabolism of clinically important drugs. Moreover CYP2D6 is also involved in the metabolism of endogenous substrates in the brain which appear highly important for psychological functioning that may be related to normal and abnormal behavioral tendencies or psychopathology. Although there are contradictory results, a lot of support has been given to the role of CYP2D6 activity on behavioral and mental functions. PMs have been consistently associated with a personality profile characterized by impulsive- and anxiety-related features. Despite these psychological features often being linked to psychopathology, there also appears to be evidence suggesting that PMs could present some protective features against the development of mental disorders. In keeping with this notion, PMs were found to perform better in a sustained attention cognitive task, which is impaired in different syndromes characterized by high vulnerability to stress and impulsivity such as schizophrenia or attention-deficit hyperactivity disorder, etc. In conclusion, there are data supporting the view that CYP2D6 may influence not only variability of drug response but also psychological functioning, and hence may be related to vulnerability to psychopathology. Copyright © 2010 S. Karger AG, Basel.

Año de publicación:

2010

Keywords:

Fuente:

scopus