Phase diagrams of lipid mixtures relevant to the study of membrane rafts

Abstract:

The present paper reviews the phase properties of phosphatidylcholine-sphingomyelin-cholesterol mixtures, that are often used as models for membrane "raft" microdomains. The available data based on X-ray, microscopic and spectroscopic observations, surface pressure and calorimetric measurements, and detergent solubilization assays, are critically evaluated and rationalized in terms of triangular phase diagrams. The remaining uncertainties are discussed specifically and separately from the data on which a consensus appears to exist. © 2008 Elsevier B.V. All rights reserved.

Año de publicación:

2008

Keywords:

• Phosphatidylcholine
• Lipid phase diagrams
• Membrane rafts
• cholesterol
• Sphingomyelin

Fuente:

scopus