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Phytochemical study of the Croton gossypiifolius bark collected in Venezuela

Abstract:

Croton gossypiifolius Vahl is a species of the Croton genus (Euphorbiaceae), which is among those known as dragon's blood due to the viscous red sap derived from its bark, widely used in traditional medicine in Latin America. As a result of a phyto-chemical study of the organic extracts obtained from the bark, three diterpenes with enf-kaurene structure were isolated: eni-kaurenoic acid (1), grandiflorenic acid (2), eni-15β-E-cinnamoiloxy- kaurenoic acid (3), one 3,4-seco-eni-kaurene diterpene known as 7-deoxo-geayine (4), the flavonoid quercitrine (5) and a series of fatty acids where palmitic proved to be the major one. These compounds were identified based on spectroscopic analysis of ID and 2D NMR and mass spectrometry. All of them are reported for the first time in this species.