A Proposed 6-Item Reduction for the European Organization for the Research and Treatment of Cancer-Quality of Core Questionnaire (EORTC QLQ-C30)-Cuban Group of Trialists on …

Abstract:

Objectives To develop an unidimensional and short version of the QLQ-C30 to be used as a patient-perceived quality of life in cancer trials. Methods We analysed data of 873 patients diagnosed with non-small-cell lung cancer who participated in 4 Cuban multicenter trials of immunotherapy against the epidermal growth factor. The analysis followed a 4-step approach. First, we conducted a Mokken nonparametric item response analysis to ascertain the QLQ-C30 dimensionality and separate several scales if appropriate. Second, we conducted a parametric Samejima’s graded response model (GRM) to assess the item characteristics and information. Third, we did a confirmatory factor analysis (CFA) to test the scales unidimensionality and to obtain standardised factor loadings to suggest a reduced version of the QLQ. Finally, we assessed the discriminative validity of the reduced version by using receiver-operator …

Año de publicación:

2013

Keywords:

Fuente:

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