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Plasmatic levels of N-terminal pro-atrial natriuretic peptide in preeclamptic patients and healthy normotensive pregnant women

Abstract:

Background and objective: To compare plasma N-terminal pro-atrial natriuretic peptide concentrations in preeclamptic patients and healthy normotensive pregnant women. Methods: A cases-controls study was done with 180 patients at Hospital Central Dr. Urquinaona, Maracaibo, Venezuela, that included 90 preeclamptic patients (group A; cases) and 90 healthy normotensive pregnant women selected with the same age and body mass index similar to group A (group B; controls). Blood samples were collected one hour after admission and prior to administration of any medication in group A to determine plasma N-terminal pro-atrial natriuretic peptide and other laboratory parameters. Results: Plasma N-terminal pro-atrial natriuretic peptide concentrations in group A (mean 1.01 [0.26] pg/mL) showed a significant difference when compared with patients in group B (mean 0.55 [0.07] pg/mL; P <.001]. There was no significant correlation with systolic and diastolic blood pressure values in preeclamptic patients (P = ns). A cut-off value of 0.66 ng/mL had an area under the curve of 0.93, sensitivity of 87.8%, specificity of 83.3%, a positive pbkp_redictive value of 84.0% and a negative pbkp_redictive value of 87.2%, with a diagnostic accuracy of 85.6%. Conclusion: Preeclamptic patients have significantly higher concentrations of plasma N-terminal pro-atrial natriuretic peptide compared with healthy normotensive pregnant women, with high pbkp_redictive values for diagnosis.