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Polydisulfide manganese(II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents

Abstract:

Purpose: To develop safe and effective manganese(II) -based biodegradable macromolecular MRI contrast agents. Materials and Methods: In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn-DTPA cystamine copolymers and Mn-EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese-based contrast agents were evaluated in mice bearing MDA-MB-231 human breast carcinoma xenografts, in comparison with MnCl 2. Results: The T 1 and T 2 relaxivities were 4.74 and 10.38 mM -1s -1 per manganese at 3T for Mn-DTPA cystamine copolymers (M n = 30.50 kDa) and 6.41 and 9.72 mM -1s -1 for Mn-EDTA cystamine copolymers (M n = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement. Conclusion: The manganese-based polydisulfide contrast agents have a potential to be developed as alternative non-gadolinium contrast agents for MR cancer and myocardium imaging. Copyright © 2011 Wiley-Liss, Inc.