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Potential uses of Swiss albins mice as model of permanent unilateral brain ischemia. Advantages on the Mongolian gerbil

Abstract:

The high incidence of cerebrovascular diseases and their consequences, together to the absence of effective treatments makes necessary to develop simple biomodels that allow to select new neuroprotective compounds. The induction of permanent unilateral brain ischemia (IUP) in Mongolian gerbil has been used from the seventies; however it presents high mortality and cognitive impairments that appear around the 7 days. The present work used swiss albins mices, obtaining 100% of survival and the cognitive impairments appeared 48 h after IUP-induced. The combination of repeated determinations of open field behavior in swiss albins mices after IUP-induced could be a simple model to evaluate the effects of new drugs on the neuronal plasticity.