Pbkp_redicting symptomatic intracranial haemorrhage after mechanical thrombectomy: The TAG score

Abstract:

Background There is limited data on pbkp_redictors of symptomatic intracranial haemorrhage (sICH) in patients who underwent mechanical thrombectomy. In this study, we aim to determine those pbkp_redictors with external validation. Methods We evaluated mechanical thrombectomy in a derivation cohort of patients at a comprehensive stroke centre over a 30-month period. Clinical and radiographic data on these patients were obtained from the prospective quality improvement database. sICH was defined using the European Cooperative Acute Stroke Study III. We compared clinical and radiographic characteristics between patients with and without sICH using χ 2 and t tests to identify independent pbkp_redictors of sICH with p<0.1. Significant variables were then combined in a multivariate logistic regression model to derive an sICH pbkp_rediction score. This score was then validated using data from the Blood Pressure After Endovascular Treatment multicentre prospective registry. Results We identified 578 patients with acute ischaemic stroke who received thrombectomy, 19 had sICH (3.3%). Pbkp_redictive factors of sICH were: thrombolysis in cerebral ischaemia (TICI) score, Alberta stroke program early CT score (ASPECTS), and glucose level, and from these pbkp_redictors, we derived the weighted TICI-ASPECTS-glucose (TAG) score, which was associated with sICH in the derivation (OR per unit increase 1.98, 95% CI 1.48 to 2.66, p<0.001, area under curve ((AUC)=0.79) and validation (OR per unit increase 1.48, 95% CI 1.22 to 1.79, p<0.001, AUC=0.69) cohorts. Conclusion High TAG scores are associated with sICH in patients receiving mechanical thrombectomy. Larger studies are needed to validate this scoring system and test strategies to reduce sICH risk and make thrombectomy safer in patients with elevated TAG scores.

Año de publicación:

2019

Keywords:

Fuente:

scopus