Prenatal, but not Postnatal, Exposure to Polychlorinated Biphenyls (PCBs) is associated with ADHD-Related Behaviors in 8-Year-Old Children

Abstract:

Background: The neurotoxicity of prenatal PCB exposure has been established in both animal and human studies. Conversely, few human studies have replicated the behavioral effects of postnatal exposures that have been observed in monkeys, possibly because of challenges to postnatal exposure estimation. To refine exposure assessment, we previously developed and validated a pharmacokinetic model to estimate children’s PCB-153 levels across development. Aims: To assess whether postnatal exposure to PCBs, estimated using a pharmacokinetic model, is associated with ADHD-related behaviors in 8-year-olds enrolled in a birth cohort study of prenatal contaminant exposure and subsequent child development. Methods: We used a published pharmacokinetic model to estimate monthly PCB-153 levels in children through 12 months of age based on parameters such as breastfeeding, cord serum PCB …

Año de publicación:

2013

Keywords:

Fuente:

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