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Presentation of the book "selected topics in basic sciences applied to the critically ill

Abstract:

The art of doing medicine is the product of an intricate and complex reasoning process, combines basic knowledge, which through pathophysiology seeks to explain the clinical manifestations that a patient presents and thereby determine a diagnosis, treatment and prognosis. The vertiginous advance in medical knowledge has revolutionized health practice and has allowed an exponential growth of information, increasingly precise and molecular; Although this is undoubtedly beneficial, it has opened important gaps between the findings in basic sciences and their application in clinical practice. The current pandemic, due to COVID-19, has been the clearest showcase of what was written in previous lines, where it was difficult to amalgamate the discoveries and publications that were shown daily on the impact of the virus at the molecular and immunological level, with the management healthcare clinician. In the book "SELECTED TOPICS IN BASIC SCIENCES APPLIED TO THE CRITICALLY ILL", we propose topics that, in our opinion, will allow anchoring key immunological concepts to the arsenal of knowledge of clinical physicians, in order to achieve holistic, reasoned management based on evidence. In seven chapters, we write about topics such as some of the different forms of cell death: NETosis, autophagy, and pyroptosis; also, you will find a space for pattern recognition receptors, of which, the TOLL type and NOD type are explained in depth; the JAK/STAT pathway is analyzed with practicality and the therapeutic targets derived from it are exposed, many of which are already in clinical application. Finally, a topic of extreme research interest, the microbiota and its role in critical illness and in human pathology in general, is addressed. As added data, we have the academic endorsement of the Faculty of Medical Sciences of the Central University of Ecuador and the review and prologues of two regional experts in the field of Immunology, who in their letters applaud the intentionality of the translational approach proposed by the book. Copyright: