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Presynaptic actions of piribedil on the cardiovascular system of the pithed rat

Abstract:

The influence of piribedil on cardiovascular sympathetic responses has been studied in the pithed rat. Piribedil (0.3–1 mg kg−1) inhibited the increases of diastolic blood pressure induced by spinal cord electrical stimulation at the level Th5‐L4. This effect was reversed by sulpiride (0.3 mg kg−1) but not by yohimbine (0.3 mg kg−1). The cardiovascular responses induced by noradrenaline were unaffected by piribedil (0.3–1 mg kg−1). However piribedil (0.3–1 mg kg−1) did not modify the heart rate increase induced by spinal cord electrical stimulation at the C7‐Th1 level. These results suggest that piribedil inhibits the vascular sympathetic transmission in the pithed rat via stimulation of presynaptic dopamine receptors. Copyright © 1986, Wiley Blackwell. All rights reserved