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Procalcitonin as early pbkp_redictor of bacteriemia in critically ill neutropenic patients

Abstract:

Background: Procalcitonin (PCT) could pbkp_redict the presence of bacteremia in critically ill patients with febrile neutropenia. The objective was to determine the pbkp_redictive value of PCT in the diagnosis of bacteremia and its ability to differentiate between gram-negative and gram-positive organisms. Methods: Retrospective cohort study conducted at the Oncology Hospital“Solón Espinosa Ayala,”Quito-Ecuador, which included patients who were admitted with febrile neutropenia to intensive therapy. PCT values were evaluated at admission together with blood culture samples, from 2010 to 2016. Results: The association between PCT levels and the diagnosis of bacteremia was investigated in 117 patients. PCT demonstrated bacteremia discrimination with a point of cut of 15.5 ng/ml and an area under the curve (AUC) of 0.76.The concentration of PCT in patients with bacteremia by gram-negative germs was higher compared with patients with bacteremias by gram-positive germs,26 vs.7.1 ng/ml (p = 0.001).Values > 26.8 ng/ml pbkp_redict bacteremia by Gram-negative bacilli (AUC: 0.81).Conclusions: A cut-off value of PCT > 15.5 ng/ml is a pbkp_redictor of bacteremia (AUC: 0.76) and values > 26.8 ng/ml pbkp_redict bacteremia by gram-negative bacilli (AUC: 0.81).