Proposal for a new grading of moyamoya disease in adult patients

Abstract:

Background: Moyamoya disease (MMD) is graded based on digital subtraction angiography (DSA) with limited clinical applications. The aim was to identify clinically relevant parameters that may be used to develop a novel MMD grading system. Methods: In 40 MMD patients bilateral revascularization surgery was performed. Clinical data including DSA, MRI and regional cerebral blood flow studies were assessed. χ 2 test corrected for dependency of measurements at the same subject and analysis of receiver operating characteristics were used to identify key parameters. Grading system included: DSA (stenosis/occlusion= 1 point; stenosis/occlusion+ intracranial compensation= 2 points; stenosis/occlusion+ intracranial compensation+ extra-intracranial compensation= 3 points), MRI (no sign of ischemia= 0 points; signs of ischemia= 1 point) and cerebrovascular reserve capacity (CVRC>–5%= 0 points; CVRC<–5 …

Año de publicación:

2011

Keywords:

Fuente:

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