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Protective effects of C-Phycocyanin against lipid peroxidation of serum lipoproteins and hepatic microsomes

Abstract:

Lipid peroxidation has been considered as deleterious phenomenon associated with diseases such as atherosclerosis and neurodegeneration. C-phycocyanin, the main active compound of the blue-green algae Spirulina platensis, has well known antioxidant properties, but its effect on lipid peroxidation has not been extensively studied. Therefore, hepatic microsomes peroxidation and lipoprotein oxidation resistance studies were undertaken and biomarkers of lipid peroxidation, such as malondialdehyde, 4-hydroxyalkenals, total hydroperoxides, conjugated dienes and peroxidation potential were spectrophotometrically determined. Our results show that c-phycocyanin has a significant inhibitory effects on lipid peroxidation (p<0.05), demonstrated by the inhibition of 80.3 % of 4-hydroxy-alkenals formation, 75.3 % susceptibility to lipid peroxidation and 47.0 % total hydroperoxides generation. This natural product conferred a significant (p<0.05) protection of plasma lipoproteins to copper/ascorbate-induced oxidation and our data show that it acts as a powerful lipid-phase antioxidant, reinforcing the current knowledge on the use of cphycocyanin as an alternative therapy for oxidative stress linked pathological conditions.