Pseudopeptide CCK-4 analogues incorporating the Ψ[CH(CN)NH] peptide bond surrogate

Abstract:

The synthesis, binding to CCK receptors, and in vitro functional activity of pseudopeptide CCK-4 analogues incorporating the (R) or (S) Ψ[CH(CN)NH] peptide bond surrogate at the Nle31-Asp32 or Trp30-Nle31 bonds are described. Z-TrpΨ[(S)CH(CN)NH]Nle-Asp-Phe-NH2 retained the high CCK-B receptor binding affinity of Boc-[Nle31]-CCK-4, and was a potent and selective CCK-B antagonist in the isolated guinea pig ileum.

Año de publicación:

1997

Keywords:

Fuente:

scopus