Regresar

QSAR analysis on tacrine-related acetylcholinesterase inhibitors

Abstract:

Background: The evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer's disease, while confirming the adverse events consisting mainly in the elevated liver transaminase levels. The study of tacrine analogs presents a continuous interest, and for this reason we establish Quantitative Structure-Activity Relationships on their Acetylcholinesterase inhibitory activity.

Año de publicación:

2014

Keywords:

  • Acetylcholinesterase Inhibitor
  • Tacrine
  • QSAR Theory
  • Alzheimer's disease
  • Validation

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso abierto

Áreas de conocimiento:

  • Relación cuantitativa estructura-actividad
  • Bioquímica
  • Farmacología

Áreas temáticas:

  • Química analítica
  • Farmacología y terapéutica

Contribuidores:

Pablo R. DuchowiczPablo R. Duchowicz
Mercader A.G.Mercader A.G.
Honarparvar B.Honarparvar B.
Saavedra L.M.Saavedra L.M.
Romanelli G.P.Romanelli G.P.
Wong K.Y.Wong K.Y.