Rapid estimation of the shelf life of acetylsalicylic acid by non-isothermal treatments using differential scanning calorimetry

Abstract:

The traditional methods for determining the stability of drugs are isothermal and require a lot of time and material resources for their execution; for this reason, it is proposed to quickly estimate the shelf life through methods that consider the kinetics of the solid state. The non-isothermal treatment of acetylsalicylic acid (ASA) samples, coming from different batches, by differential scanning calorimetry allowed the application of Kissinger method to calculate the activation energy and the pre-exponential factor of the degradation process; these values were contrasted with those obtained from ASA/salicylic acid binary mixtures, of similar composition to the raw material. There was not significant difference between these kinetic parameters and therefore, they were grouped and characterized by an isokinetic point. The residual shelf life estimated for the raw material constituted by crystals with lower specific surface area …

Año de publicación:

2019

Keywords:

Fuente:

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