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Rat liver microsomal progesterone metabolism: Evidence for differential Troleandomycin and pregnenolone 16α-carbonitrile inductive effects in the cytochrome P-450 III family

Abstract:

The effect of Troleandomycin (TAO)† and pregnenolone 16α-carbonitrile (PCN) on the hepatic microsomal progesterone metabolism in the rat is evaluated. Over thirteen hydroxylated progesterone derivatives are detected, including the novel 6β,21-, 6β,16α-, 6β,16β- and 2,21-dihydroxy derivatives, suggesting the induction of several cytochrome P-450 isozymes. PCN treatment results overall in an augmented production of progesterone metabolites whereas TAO treatment both induces and represses specific hydroxylase activities. Progesterone metabolism with purified isozymes isolated from liver microsomes from TAO and PCN treated rats differs significantly from that observed with intact microsomes, reflecting the complexicity of the induction pattern of the cytochrome P-450 III family. © 1989.

Año de publicación:

1989

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Bioquímica
    • Bioquímica
    • Bioquímica

    Áreas temáticas:

    • Farmacología y terapéutica
    • Bioquímica

    Contribuidores:

    Maurel P.Maurel P.
    LANGE R.LANGE R.
    Christian LarroqueChristian Larroque
    van Lier J.E.van Lier J.E.
    Langlois R.Langlois R.