Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation …

Abstract:

Aims To compare effects of heparin and hirudin on biochemical markers of coagulation. Methods and Results Patients (n=395) with unstable angina or myocardial infarction without ST elevation were randomized to a 72-h infusion of one of three regimens: unfractionated heparin (bolus of 5000IU followed by an infusion of 1200IU.h−1), low-dose hirudin (HBW 023; 0·2mg.kg−1bolus followed by 0·10mg.kg−1.h−1) or medium-dose hirudin (0·4mg.kg−1bolus followed by 0·15mg.kg−1.h−1). Infusions were adjusted to maintain an activated partial thromboplastin time of between 60–100s. Activated partial thromboplastin time, prothrombin fragment 1.2 (F1.2), thrombin antithrombin III complex and D-dimer were measured before, during and after the infusion. Median activated partial thromboplastin time was similar in the two groups early on, but was significantly lower in the heparin group than in the …

Año de publicación:

2000

Keywords:

Fuente:

google