Reduced levels of serum FGF19 and impaired expression of receptors for endocrine FGFs in adipose tissue from HIV-infected patients

Abstract:

Background: To determine the role of fibroblast growth factor (FGF)-19 and FGF21 and the endocrine FGFs receptor system in the metabolic alterations that manifest in HIV-1–infected patients undergoing highly active antiretroviral treatment (HAART). Methods: Serum FGF19 and FGF21 levels were determined in 4 groups of individuals as follows:(1) HIV-1–infected HAART patients with lipodystrophy (n= 38); or (2) without lipodystrophy (n= 34);(3) untreated (naive) HIV-1–infected patients (n= 34); and (4) healthy controls (n= 31). Serum FGF19 levels were correlated with anthropometric, metabolic, HIV-1 infection–related, and HAART-related parameters and with FGF21 levels. The gene expression of FGF receptor 1 and the coreceptor β-Klotho was analyzed in adipose tissue from 10 individuals from each group. Results: Serum FGF19 levels were significantly reduced in all groups of HIV-1–infected patients, whereas …

Año de publicación:

2012

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