Regioselective synthesis of trifluoromethylated 3-(pyrazolyl)indoles on the basis of 6-(trifluoromethyl)comanic acid

Abstract:

A number of trifluoromethylated 3-(pyrazolyl)indoles was synthesized from 2-(trifluoromethyl)comanic acid, its ethyl ester and amide via intermediate isomeric 5(3)-[3,3,3-trifluoro-2-(phenylhydrazono)propyl]pyrazole-3(5)- carboxylic acids and their derivatives. © 2011 Elsevier B.V. All rights reserved.

Año de publicación:

2012

Keywords:

• regioselectivity
• Trifluoromethylated heterocycles
• 6-(Trifluoromethyl)comanic acid
• Fischer reaction
• 3-(Pyrazolyl)indoles

Fuente:

scopus