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Resistance training improved lipid profile and lipoperoxidation in adults with intellactual disablity

Abstract:

Resistance training has received less attention than endurance training in individuals with intellectual disability in general and Down syndrome in particular. It would be of great interest to compensate this imbalance given muscle strength is essential on functional tasks of daily living and employability in this group. To achieve this goal, this is the first study conducted to determine the effect of resistance circuit training on lipoperoxidation in sedentary adults with DS, given promising results reported in previous studies focused on aerobic training. A total of forty young male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities and their families. They all had medical approval for physical activity participation. Twenty-four were randomly assigned to perform a resistance circuit training with 6 stations, 3 days per week for 12 weeks. Exercise intensity was based on function of the 8RM assessments. Control group included 16 age, sex and BMI matched adults with Down syndrome. Plasma levels of oxidized low-density lipoprotein (oxLDL) were assessed by commercial ELISA-kits. Serum lipid profile and fat mass percentage were also determined.This protocol was approved by an Institutional Ethics Committee. When compared to baseline results, plasma levels of oxLDL were significantly decreased after the completion of the training program. Serum lipid profile and fat mass were significantly improved too. Neither sports-related injuries nor withdrawals from the program were reported during the entire study period. Finally, no changes were observed in the control group. It was concluded resistance circuit training improved lipoperoxidation in male sedentary adults with DS. Further, long-term, well-conducted studies are required to determine whether the increased antioxidant system may improve clinical outcomes of adults with DS.