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Resistin is associated with C reactive protein and cardiovascular risk markers in obese children

Abstract:

The aim of this study was to evaluate seric levels of resitin and their association with highsensitivity C Reactive Protein (hsCRP), nitric oxide (NO) and plasmatic lipids (PL) in a pediatric age population. A total of 366 children and adolescents (between 10-16 years old) participated, and were grouped into eutrophic (n=162) and obese (n=204). Weight, height, waist circumference, resistin, fasting blood glucose and insulin levels, PL, hsCRP, NO, malondialdehyde and blood pressure were measured. BMI, waist to height ratio (W/HR) and HOMAIR were calculated. Tstudent, ANOVA, MannWhitney Uvalue or KruskalWallis were used to compare between groups and Spearman correlation was used to determine association among variables. Male obese subjects showed higher resistin levels (p<0.05). Female subjects showed higher resistin values in the eutrophic group (p=0.012) and in the normal W/HR (p=0.011). At higher levels of resistin, the eutrophic group showed higher levels of triacylglycerides, but the obese group showed lower triacylglycerides, HDLc and NO levels and higher hsCRP levels and BMI. These results suggest that resistin could be a risk factor for cardiovascular disease because of its positive association with hsCRP and inverse association with NO and HDLc, parameters involved in inflammation and endothelial dysfunction.