Regresar

Rhizophora mangle L. effect on experimental ulcerative colitis in rats

Abstract:

INTRODUCTION: Rhizophora mangle L. is a plant with a high level of distribution in Cuba, which has many scientifically demonstrated effects on gastroduodenal ulcers, healer, antiinflammatory, antioxidant, as well as a high intestinal absorption and a possible activity on ulcerative colitis. OBJECTIVES: To establish the effect of dry aqueous extract of R. mangle barks on ulcerative colitis in two experimental models in rats. METHODS: We performed a study on induction of ulcerative colitis by intracolon administration of doses 24, 50 and 100 mg of dry matter/mL of extract solution, and a negative control group. In a experimental second model by induction of colitis from sulfuric trinitrobenzene acid we carried out a previous administration over 3 d of dose levels (50, 100, 250 or 500 mg/kg per os). RESULTS: Dry aqueous extract of R. mangle per os and intracolon showed a moderate effect on ulcerative colitis with a light decrease in clinical, pathologic and inflammatory parameters in experimental model of induction with acetic acid. In model of sulfonic trinitrobenzene acid-induced acute and chronic ulcerative colitis there was not evidenced significant antiinflammatory effect. CONCLUSIONS: Dry aqueous extract of R. mangle barks has a moderate action on experimental ulcerative colitis in rats.