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A combination of circulating chemokines as biomarkers of obesity‐induced insulin resistance at puberty

Abstract:

Background In obesity adipose tissue undergoes structural re‐modelling leading to a chronic low‐grade inflammatory state linked to insulin resistance (IR). Objective We aimed to develop a clinically relevant biomarker model for stratifying IR in adolescents with obesity. Methods Cytokines [tumour cell derived factor 1α, monocyte chemoattract protein (MCP) 1, eotaxin and fractalkine], growth factors [brain‐derived neurotrophic factor, pro‐fibrotic platelet‐derived growth factor (PDGF‐BB) and insulin‐like growth factor 1] and biochemical/metabolic factors were analysed in serum of 143 pubertal patients with obesity (50% IR; 50% non‐IR) and 33 controls. Factor analysis, correlation, binary logistic regression and receiver operating characteristic analysis were used to evaluate combinations of these biomarkers as possible diagnostic tools for IR. Results Two biomarker IR models combining levels of triglycerides …