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Role of cdk5 on ATM phosphorylation in neuronal death induced by DNA damage

Abstract:

This study demonstrates that Cdk5 phosphorylates ataxia-telangiectasia mutated protein (ATM) at Ser794 in postmitotic neurons when DNA damage is induced. Moreover, the authors describe that phosphorylation at Ser794 is required for autophosphorylation of ATM at Ser1981 and is necessary for its activation. They show that phosphorylation of ATM by Cdk5 plays a key role as a regulator of p53 and H2AX phosphorylation and function, which are direct targets of ATM. Cdk5-ATM pathway interruption protects neurons from cell death since it reduces cell cycle re-entry and the expression of PUMA and Bax, which are targets of p53. © 2009 Future Medicine Ltd.

Año de publicación:

2009

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Biología molecular
    • Neurología
    • Neuropsicología

    Áreas temáticas:

    • Fisiología humana
    • Fisiología y materias afines
    • Enfermedades

    Contribuidores:

    Pallás M.Pallás M.
    Verdaguer E.Verdaguer E.
    Junyent F.Junyent F.
    Antoni CaminsAntoni Camins