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Second harmonic generation microscopy for label-free imaging of fibrillar-like mesostructured polysulfone biomaterials

Abstract:

Polysulfone (PSF) has been used as a biomaterial for decades. But label-free, microscopic imaging in situ is challenging for this material. Here, we present using second harmonic generation (SHG) microscopy to directly image PSF, a well-studied biomaterial, in situ. The polar and fibrillar mesostructure of PSF was clearly revealed, indicating it is a SHGactive biomaterial. With its new nonlinear optical property, PSF could become an interesting scaffolding biomaterial for tissue engineering or a theranostic nanogent for drug delivery and disease diagnostics.