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Sepsis-Related Outcomes of Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Abstract:

We analyzed the National Inpatient Sample (NIS) database to study the sepsis-related outcomes in patients with Philadelphia negative myeloproliferative neoplasms (MPN). A total of 82,087 patients were included, most had essential thrombocytosis (83.7%), followed by polycythemia vera (13.7%), and primary myelofibrosis (2.6%). Sepsis was diagnosed in 15,789 (19.2%) patients and their mortality rate was higher than nonseptic patients (7.5% vs 1.8%; p <.001). Sepsis was the most significant risk factor of mortality (aOR, 3.84; 95% CI, 3.51–4.21), others included liver disease (aOR, 2.42; 95% CI, 2.11–2.78), pulmonary embolism (aOR, 2.26; 95% CI, 1.83–2.80), cerebrovascular disease (aOR, 2.05; 95% CI, 1.81–2.33), and myocardial infarction (aOR, 1.73; 95% CI, 1.52–1.96).