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Sequential Use of Topical Imiquimod and Photodynamic Therapy in Extramammary Paget’s Disease: Disease and Treatment Update and Review of the Literature

Abstract:

Purpose: Extramammary Paget’s disease (EMPD) represents an intraepithelial carcinoma whose diagnosis is often delayed as it can be easily misdiagnosed as a benign inflammatory dermatosis. Surgery is considered to be the standard treatment, but all surgical modalities are associated with high local recurrence rates. Methods: We give concern of this disease through the description of a case of primary EMPD in an 83-year-old lady treated with an alternative modality of treatment: the sequential use of topical imiquimod and photodynamic therapy. Results/Conclusion: Topical treatments can be an alternative, and when used in combination, it allows increasing tolerance and, therefore, treatment compliance and satisfactory outcomes.