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Serum levels of nitric oxide in patients with hipertensive crises

Abstract:

A prospective clinical study was designed with the purpose to measure nitric oxide (NO), in patients with hypertensive crises (HC). Blood samples were collected from 10 normotense and/or pre-hypertensive individuals (group A), 9 with hypertension (AHT) stages 1 and/or 2 (group B), and 9 with HC but with hypertensive urgency (group C). Systolic and diastolic blood pressure (BP) was recorded by Dynamap and NO was measured by diazotization assay. NO values in group B and C were lower than A group (p<0.001), however, when B and C groups were compared, there was no significant differences between both groups. NO levels were negative correlated with systolic and diastolic BP. We concluded that NO is low in hypertension and HC, but the association between NO and HC with respect to AHT stages 1 and 2 was not corroborated. Further researches are needed to identify vasoconstrictor factors that may lead the suddenly elevation of BP levels founded in HC.