Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau

Abstract:

Importance The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger association among women compared with men. Yet limited work has evaluated the association betweenAPOEalleles and markers of AD neuropathology in a sex-specific manner. Objective To evaluate sex differences in the association betweenAPOEand markers of AD neuropathology measured in cerebrospinal fluid (CSF) during life or in brain tissue at autopsy. Design, Setting, and Participants This multicohort study selected data from 10 longitudinal cohort studies of normal aging and AD. Cohorts had variable recruitment criteria and follow-up intervals and included population-based and clinic-based samples. Inclusion in our analysis requiredAPOEgenotype data and either CSF data available for analysis. Analyses began on November 6, 2017, and were completed on December 20, 2017 …

Año de publicación:

2018

Keywords:

Fuente:

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