Sharing kidneys across donor‐service area boundaries with sensitized candidates can be influenced by HLA C

Abstract:

Bryan CF, Luger AM, Smith JL, Warady BA, Wakefield M, Schadde E, Murillo D, Nelson PW. Sharing kidneys across donor‐service area boundaries with sensitized candidates can be influenced by HLA C. Clin Transplant 2010: 24: 56–61. © 2009 John Wiley & Sons A/S. Abstract:  The United Network for Organ Sharing (UNOS) implemented the virtual crossmatch system in UNet as a way to improve the likelihood of a negative crossmatch when kidneys are shared with HLA‐sensitized candidates across donor service area (DSA) boundaries. The role of HLA C in that process is not universally appreciated. We recently experienced an unexpected positive flow T and B cell crossmatch for an imported, HLA zero‐mismatched kidney because of donor‐specific HLA C antibodies and transplanted it into the backup candidate. HLA C locus antigens were not typed by the OPO’s laboratory that sent the kidney so the UNet …

Año de publicación:

2010

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