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Siamese depsipeptides: Constrained bicyclic architectures

Abstract:

The first members of a new class of depsipeptides with tartaric acid as the core unit, called Siamese depsipeptides, are described. These compounds were synthesized from a branched precursor in only one cyclization step. The structural manipulation of a natural bioactive depsipeptide (sansalvamide A) gives analogues with greater activity, and thereby provides additional information on structure-activity relationships (see structures). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Año de publicación:

2009

Keywords:

  • Tartaric acid
  • biological activity
  • Structure-activity relationships
  • Bioorganic chemistry
  • Depsipeptides

Fuente:

scopusscopus
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Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

    Áreas temáticas:

    • Farmacología y terapéutica
    • Química orgánica

    Contribuidores:

    Ruíz-Rodríguez J.Ruíz-Rodríguez J.
    Alberício F.Alberício F.
    Jan SpenglerJan Spengler