Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

Abstract:

A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions. © 2007 Wiley Periodicals, Inc.

Año de publicación:

2007

Keywords:

• Ester peptides
• Automated solid-phase depsipeptide synthesis
• Helical coiled coil peptides

Fuente:

scopus