Solid phase synthesis of 3-(5'-carboxypentyl)-5-substituted tetrahydro- 2H-1,3,5-thiadiazin-2-thione derivatives

Abstract:

The solid phase synthesis of 3-(5'-carboxypentyl)-5-substituted tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives 5 is described. 6-Amino- n-hexanoic acid was attached via its C-terminal to hydroxymethyl polystyrene using a 'SASRIN' linker. The bound amino acid was converted to the corresponding dithiocarbamate 3 followed by cyclization in the presence of formaldehyde and the corresponding free amino acids to afford 3-(5'- carboxypentyl)5-substituted tetrahydro-2H-1,3,5-thiadiazin-2-thiones 4. The final products were cleaved from the resin and obtained in moderate yields. (C) 2000 Elsevier Science Ltd.

Año de publicación:

2000

Keywords:

• solid-phase synthesis
• Resins amino acids
• Thiadiazin-2-thiones

Fuente:

scopus

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