Solid-phase peptide synthesis using N^α-trityl-amino acids

Abstract:

The preparation of Nα-trityl-amino acids is described. Several derivatives of trifunctional amino acids carrying acid- and base-labile side-chain protecting groups and the trityl group at the Nα position are prepared for first time. The incorporation of Nαtrityl-amino acids into peptide sequences using solid-phase protocols was achieved. The use of the trityl group for the protection of the α-amino group in conjunction with base-labile side-chain protecting groups constitutes a new method for the assembly of peptides in mild conditions.

Año de publicación:

2001

Keywords:

• Amino acid derivatives
• Amino protection
• N-trityl-amino acids
• Solid phase peptide synthesis
• Protecting group

Fuente:

scopus