Solvent-free synthesis of 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones under microwave irradiation

Abstract:

4-Aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones have been prepared in one-pot condensation from Meldrum's acid, methyl acetoacetate and the appropriate benzaldehyde in the presence of ammonium acetate using microwave irradiation without solvent. This rapid method produced pure products in high yields (81-91%) due essentially to a specific non-thermal microwave effect (17-28%) by conventional heating under the same conditions. © 2003 Elsevier Science Ltd. All rights reserved.

Año de publicación:

2003

Keywords:

• Solvent-free synthesis
• dihydropyridones
• Microwave irradiation

Fuente:

scopus

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