" Electrospinning Methods for the Production of Resorbable Bifurcated Vascular Grafts: Influence of process parameters on mandrel adherence and mechanical properties

Abstract:

Materials and Methods Cardiovascular disease is the most common cause of death. This disease causes 31% of all global deaths annually [1]. Many of these conditions can be treated by a vascular graft. Similarly, every pancreatic surgeon finds a way construct pancreatic anastomosis after pancreatoduodenectomy [2]. This work presents the evaluation of electrospun bifurcated stents (EBS) to meet specific requirements needed in end-to-side anastomosis, popular surgical procedures to connect one side or more of the arteries or veins. Previously we reported a proof of concept about the construction of complexly shaped bifurcated grafts [3]. Pressurized burst strength test (Goal: 2000mmHg–4000mmHg [4]) and suture retention strength (goal: 2N [5]) were conducted as specified in ISO 7198: 2016. A bifurcated mandrel was designed and printed via continuous Digital Light Processing (cDLP). Electrospinning and a 2 degree of freedom (2-DOF) mechanism were used to apply electrospun polymer fibers onto the bifurcated mandrel. Both mandrel and fibers were produced with biocompatible materials that have previously been approved by the Food and Drug Administration (FDA) for use in similar devices.

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