Statistical versus clinical significance of the cure study in acute coronary syndromes

Abstract:

With respect to cost-effectiveness of clopidogrel in acute coronary syndromes, data from the CURE study (6) show that the cost per event avoided with clopidogrel in the study is comparable to other cost-effective therapies in cardiovascular disease. Strategies to prevent major cardiovascular events such as MI, cardiovascular death, and stroke are clinically important. Preventing two events per 100 people for nine months of therapy is comparable to most other treatments in the prevention of cardiovascular events, including aspirin, beta-blockers, angiotensin-converting enzyme inhibitors, and statins in patients following MI (7). Moreover, the cumulative impact of these various strategies add up to a large benefit. Therefore, we believe that CURE is not only statistically significant, but also that the results are clinically relevant and important.

Año de publicación:

2003

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Fuente:

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