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Stress and antioxidant vitamins in type 2 diabetic patients

Abstract:

Hyperglicemia increases free radicals generation, surpassing the antioxidant defense capacity. Objective: to assess the oxidative stress, antioxidant defense, and consumption of food rich in vitamins A and E, in 24 patients aged 35-55 years with recent diagnosis of type 2 diabetes, attending to the HUAL Diabetes Unit Care in 2004 and the HVS Diabetes Unit Care in 2005. Methodology: The malondialdehyde (MDA) concentration was assessed to evaluate the oxidative stress using the tio-barbituric acid-reactive substances (TBARS) method. The antioxidant defense was assessed by the serum concentration of vitamins A and E through high-performance liquid chromatography; total cholesterol (CT) and triglycerides (TG) were assessed by the colorimetric enzymatic method and the consumption of food rich in antioxidants, using a food-consumption questionnaire. Outcomes: MDA was within normal limits (1.617±1.520mm/l); antioxidant vitamins A, E, and lipids-standardized vitamin E, were below the cut-off point for antioxidants (44.372±25. 411μg/dl, 1051.704±499.805 μg/dl and 1090.041±665.89 μg/dl respectively); the vitamin E consumption was 16432.02±22552.55 μg, and the vitamin A consumption reached values of 1863.325±1559.677 μg. Conclusions: An oxidative stress in early stages of Diabetes was not observed, except for a decrease in serum levels of vitamins A and E, which can be due to the decrease in the consumption of vitamin E, as the vitamin A was above the antioxidant levels.