Successful renal transplantation despite low levels of donor‐specific HLA class I antibody without IVIg or plasmapheresis

Abstract:

Abstract:  We prospectively transplanted 10 primary kidney recipients with deceased donor organs (nine kidney and one pancreas/kidney) when their flow cytometric T‐cell IgG, HLA class I donor‐specific crossmatch was positive but the AHG T‐cell crossmatch was negative, with a median follow‐up of 1.8 yr. No pre‐ or peri‐operative IVIg or plasmapheresis was administered to any patient. All but one of the 11 organs transplanted into patients with a flow T+/AHG− crossmatch is currently functioning despite the continued presence of circulating low levels of HLA class I antibody. Flow HLA class I antigen‐coated beads showed the presence of at least one donor‐specific HLA class I antibody at transplantation in each of the 10 cases. No rejections were observed in seven of the 10 cases (70%). Six rejection episodes, four cellular and two humoral, occurred in three patients. Each rejection was successfully treated …

Año de publicación:

2006

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Fuente:

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