Super-cationic peptide dendrimers—synthesis and evaluation as antimicrobial agents
Abstract:
Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.
Año de publicación:
2021
Keywords:
- Gram-negative
- Solid-phase peptide synthesis
- Therapeutic index
- Antimicrobial peptides
- Gram-positive
Fuente:
scopusTipo de documento:
Article
Estado:
Acceso abierto
Áreas de conocimiento:
- Biotecnología
- Resistencia antimicrobiana
- Microbiología
Áreas temáticas:
- Química orgánica
- Microorganismos, hongos y algas
- Farmacología y terapéutica
