Superoxide anion in lesions of cervix associated or not papillomavirus-infection

Abstract:

Objective: To determine the expression of superoxide anions in premalignant and malignant lesions of the cervix associated or not with human papillomavirus (HPV). Methods: A total of 74 patients (45 CINI, 5 CIN II, 5 CIN III and 5 patients with Cancer) 7 women who had inflammation and 7 apparently healthy women as controls, were sampled for cytology, cervical exudate HPV and 2 biopsies determine: 1) fixed in 10% formalin for histological analysis, 2) component in OCT (Tissue Tek) to determine the expression of superoxide anions by reaction of Briggs, one carries out the identification and genotyping of HPV Hybrid Capture (HC2). Results: Of the patients studied 23% were positive for HPV infection with a 58.5% high-risk genotypes were significant differences in the number of superoxide anion positive cells in both epithelium and stroma in different degrees of damage observed increased as the degree of …

Año de publicación:

2010

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Fuente:

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