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Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Abstract:

(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.