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Supervised resistance training reduced oxidative damage in adults with Down Syndrome

Abstract:

Aim. This was the first study undertook to determine the influence of resistance circuit training on reducing oxidative damage in sedentary adults with Down Syndrome (DS). Methods. A total of forty male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities. All of them had medical approval for physical activity participation. Twenty-four were randomly assigned to perform a resistance circuit training with 6 stations, 3 days per week for 12 weeks. Training intensity was based on function of the 8-repetition-maximum (8RM) test per each exercise Control group included 16 age, sex and BMI matched adults with Down syndrome. Main outcome measures included plasma antioxidant capacity as well as levels of malondialdehyde (MDA) and carbonyl groups. Furthermore, urinary levels of 8-hydroxydeoxyguanosine (8OHdG) and maximal handgrip strength were also determined. Results. When compared to pre-test values, resistance training significantly reduced plasma MDA (0.46±0.13 vs. 0.34±0.11 mmol/L; P=0.0162) and urinary 80HdC (8.8±1.3 vs. 7.5±1.1 nmol/L; P=0.0231). Furthermore, it significantly increased ferric reducing ability of plasma and maximal handgrip strength. No changes were found in the control group. Conclusion. Resistance training program reduced oxidative damage in male adults with DS by increasing antioxidant capacity. Further, long-term, well-conducted studies are required to determine whether it improves clinical outcomes of adults with DS.