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Synthesis and Biological Evaluation of a Teixobactin Analogue

Abstract:

The first synthesis and biological activity of a teixobactin analogue is reported. Substitution of the unusual l-allo-enduracididine residue by the naturally occurring l-arginine was achieved, and the analogue gave an activity trend similar to that of teixobactin (against Gram-postive bacteria) and meropenem, which was approved by the FDA in 1996. The synthetic route used allows for the synthesis of the natural product as well as the development of a program of medicinal chemistry.

Año de publicación:

2015

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Antibiótico
    • Farmacología
    • Farmacología

    Áreas temáticas:

    • Farmacología y terapéutica
    • Dirección general
    • Bioquímica

    Contribuidores:

    Govender T.Govender T.
    El-Faham A.El-Faham A.
    Alberício F.Alberício F.
    Kruger H.G.Kruger H.G.
    B. G. De la TorreB. G. De la Torre
    Jad Y.E.Jad Y.E.
    Acosta G.A.Acosta G.A.
    Ramtahal M.Ramtahal M.
    Naicker T.Naicker T.